HOUSTON -- News this week about a breakthrough treatment for Alzheimer's disease is getting mixed reactions from some researchers, including in Texas.
The drug attempts to treat a possible cause of the neurodegenerative disease, rather than only treating the symptoms.
Dr. George Perry, professor and Semmes Foundation Distinguished University Chair in Neurobiology at the University of Texas at San Antonio and editor of the Journal of Alzheimer's Disease, the largest subscriber publication in the field, said the announcement by the U.S. Food and Drug Administration (FDA) was a surprise, and for him, a disappointment.
"The trial that was done had over 3,000 people, cost over $1.5 billion to do, it was done exceptionally well. Now, the analysis that of the data after, mathematically, was ridiculous," Perry asserted.
Perry contended the FDA rushed to approve the drug, despite data he said demonstrated the treatment was not effective.
On Friday, a prominent Harvard drug researcher became the third member of the FDA's advisory committee to resign over the agency's decision to approve aducanumab, saying he's not convinced of its effectiveness. Harvard's Aaron Kesselheim called the FDA approval "probably the worst drug approval decision in recent U.S. history."
Researchers, such as Perry, said the FDA's decision to green-light the drug might discourage development of other treatments with greater cognitive benefits. He believes its approval could set the research community back 10 to 20 years, by discouraging funding to research more effective treatments.
"This was reviewed by a panel of experts; not experts in Alzheimer's disease, experts in data analysis for drug approval," Perry explained. "Eleven of them said that the data didn't show effectiveness, and one of them abstained, and the FDA approved it anyway."
In Texas, the Alzheimer's Association said at least 400,000 people are currently living with Alzheimer's, with an anticipated increase in cases of more than 22% expected by 2025.
Drug-maker Biogen has priced the drug at $56,000 a year for an average patient, but said the vast majority of Alzheimer's patients will be covered by Medicare, as many are over age 65.
This story was updated Fri., June 11, 3:10 p.m. MDT, to include information about the resignation of Aaron Kesselheim, and updated Mon., June 14, 5:45 p.m. to clarify concerns about the decision.
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A health care workforce shortage in New Hampshire is leaving Alzheimer's patients and their families with few options for treatment.
Patients facing a possible diagnosis are having to wait more than six-months to see a neurologist and are often forced to travel long distances.
Melissa Grenier, regional manager for the Alzheimer's Association of New Hampshire, said while patients wait, the disease progresses and families feel the financial and emotional strain.
"We want people to have the earliest and the most accurate diagnosis possible so that they can implement the best treatments," Grenier urged. "They can plan for the future."
New Hampshire has the most job openings in health care per capita and will need a more than 100% increase in geriatricians to meet demand by 2050.
Grenier pointed out 26,000 people in the state live with Alzheimer's disease and the number will grow to 32,000 next year.
State lawmakers are considering a bill to help build the pipeline of health care workers needed for what has been dubbed the "silver tsunami" of Alzheimer's and dementia patients. Senate Bill 403 would create a rural residency program, expand student loan repayments for medical workers and help expose more students to health care careers.
For now, Grenier noted the state has just 10 respite care facilities for people with Alzheimer's and demand is growing.
"I do not think that New Hampshire has the infrastructure to support our aging population and our growing population of people with memory impairment," Grenier asserted. "And subsequently, the number of people caring for those folks."
Grenier emphasized respite centers offer families a more affordable option compared to home health services, but those living in the state's lakes region or north country have even fewer options. She added people often call the Alzheimer's Association 24-hour hotline looking for advice on the difficult health care decisions they face each day.
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Summer will be here before you know it, and experts say now is the time to get prepared for Arizona's scorching and life-threatening temperatures.
Some 645 heat-associated deaths were confirmed by Maricopa County's Department of Public Health in 2023, breaking the previous year's record by more than 50%.
Dr. Rebecca Sunenshine, the health department's medical director, said the 2023 Heat Related Deaths Report demonstrates this is a significant public health concern for Arizona's most populous county.
"This is really a call to action," she said, "to make sure that we all come together across the county - community-based organizations, cities, the county government - to prevent these deaths almost all of which are preventable."
In 2023, an average of 13 heat related deaths per day occurred during July, with people who were unhoused making up the largest proportion. With hotter months on the way, Sunenshine encouraged Arizonans to check on neighbors and seniors who may live alone, make sure air conditioning systems are working and follow the county's "10 tips" to stay safe in the heat.
In addition to tracking heat-related deaths, the Department of Public Health also conducted an evaluation of cooling and respite centers that were part of Maricopa County's Heat Relief Network last year. Sunenshine said they learned valuable details - including that two-thirds of respondents didn't have a stable home, and that many people found the cooling centers only through roadside signs advertising them.
"Some of the biggest barriers to accessing cooling centers are not knowing they exist, not knowing where they're located and not having transportation," she said, "and we based all our actions this upcoming summer on the results of this cooling center evaluation."
She said they were able to establish a call center, operated by bilingual community health workers, to help connect people not only to heat-relief resources but to energy and security-assistance programs.
Arizonans can call 211 to help find transportation to the nearest heat-relief location, when they open again on May 1.
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This week, an Alabama group is drawing attention to the need for Medicaid expansion.
Currently, approximately 300,000 people are stuck in a health care coverage gap, earning too much for Medicaid but not enough for private insurance.
Debbie Smith, Cover Alabama campaign director for Alabama Arise, said they are reaching out to legislators statewide and sharing information about the stakes involved.
"About 19 of our rural hospitals are at risk of immediate closure," Smith reported. "That means they are at risk of closing in the next year. And having patients that come in that don't have health insurance coverage is not good for their bottom lines."
The Cover Alabama Coalition is engaging lawmakers through meetings in their districts and encouraging residents to share their experiences and thoughts on Medicaid expansion via social media. Although 19 rural hospitals are due for immediate closure, a report on rural hospitals from advisory firm Chartis highlighted more could be at risk in the long run. The report revealed nearly 74% of Alabama's rural hospitals are operating at a loss.
Smith sees Medicaid expansion as a life-or-death matter, which can greatly enhance the quality of life for many residents. She noted it would provide access to preventive care and vital medications, and can help people enter or remain in the workforce. She pointed out the current Medicaid threshold creates barriers for families in need.
"Let's say a single mom with two kids, she can't make more than $4,656 a year and still qualify for Medicaid unless she has a disability or is pregnant," Smith observed. "And at the other end of the perspective, they have to make at least around $25,000 to qualify for the health insurance marketplace."
She added the expansion could also benefit around 5,000 veterans who lack coverage. Currently, 41 states including District of Columbia, have already expanded Medicaid. Mississippi has also recently passed legislation in its House, it is now waiting for a Senate vote.
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