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Minnesota public safety agencies reeling from weekend tragedy; Speaker Johnson faces critical decision on Ukraine aid; Public comment sought on proposal to limit growth in health-care costs; MS postal union workers voice concerns about understaffing, mail delays.

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Truckers for Trump threaten to strike over his massive civil fine for business fraud in New York City. Biden wants Norfolk Southern held accountable one year after an Ohio derailment and dangerous chemical spill and faith leaders call for peace in the Israel-Hamas war.

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Drones over West Texas aim to improve rural healthcare, the Ogallala Aquifer, the backbone of High Plains agriculture, is slowly disappearing and federal money is headed to growers of wool and cotton.

Indiana University Awarded $50 Million to Continue Alzheimer’s Research

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Tuesday, November 1, 2022   

November is Alzheimer's Disease Awareness Month, and researchers at Indiana University were recently awarded $50 million to study the field further. Research into late-onset Alzheimer's disease continues under the MODEL-AD protocol, which was established at I-U in 2016 and develops models of disease progression in mice and then opens those models to other researchers.

Gene editing of mice is used to create genetic risk variants that are seen in humans. Dr. Bruce Lamb, executive director, Stark Neurosciences Research Institute, IU School of Medicine.said the models that look like they are progressing towards disease are studied in a more in-depth fashion and then released to the broader scientific community.

"All of the models and all of the data also are made available to the entire scientific community, without any regulations on who can access them." Lamb said. "Within six months after quality control, all of our data, all of the animals are then made available to the scientific community."

Researchers have created more than 40 animal models since the project began.

The MODEL-AD protocol is reliant on gene-editing technology to create the same genetic conditions that are seen in human Alzheimer's patients. Lamb said gene editing has revolutionized the process.

"Where the field has been really revolutionized is by CRISPR gene editing." Lamb said. "So pretty much all of the models we're generating are using CRISPR at some point in that process, to specifically try to model specific variants seen in humans, in mice."

The funding award will keep the MODEL-AD project going through at least 2026.


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