CHARLESTON, W.Va. — Brain science can help explain why people with serious addictions are so out of control, and why many addicts have trauma in their history.

Jessica Holton is a licensed clinical social worker and addiction specialist teaching in Charleston this week. She said in her practice, almost all of the addicts have trauma in their background, as well as Substance Abuse Disorder. Holton said this is because both addiction and trauma take over the limbic system - the animal part of the brain - bypassing the rational decision-making part.

"We often think that it's a choice, a moral failure. But really the science shows that the survival part of the brain, the limbic system, actually gets hijacked for those who have a true addiction,” Holton said.

Addicts sometimes say it's as if they've lost control of their own hands. Holton describes that as a symptom.

She'll be in Charleston for the Spring Conference of the National Association of Social Workers, West Virginia. That conference starts Wednesday. It's the largest event of its kind in the country. This year's schedule also includes discussions of foster care and social work in schools.

The limbic system controls pleasure and fear, and the out-of-control impulses known as the fight-or-flight response we experience when threatened. Holton said for those experiencing a trauma, or reliving one, the limbic system is pumping out fear messages that can override everything else.

She said drugs - at least at first - make the system put out pleasure messages. That's part of why people with post-traumatic stress disorder are vulnerable to Substance Abuse Disorder.

"Addiction tends to help people numb out and helps them to avoid,” Holton said. “In trauma, that same part of the brain works in overdrive. So it makes sense as to why when the brain is overreacting and over-responding and everything is a threat, substance use and trauma tend to go hand in hand."

Fairly quickly, serious substance abuse can overwork the limbic system's ability to create pleasure, which is why addicts say they no longer enjoy it. They just take substances to avoid withdrawal, a big part of which is the limbic system sending out fear messages.

Holton said the good news is that even if addiction can't be cured, an addict's limbic system can return to a state closer to normal after some months sober.


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The State of Indiana wants to learn more about Hoosiers' experiences with substance-use disorder and addiction-recovery services.

Administered by the state's Division of Mental Health and Addiction (DMHA), the "Recovery Capital Index" will take a holistic look at the addiction-recovery resources available to people across the state, to help determine whether further resources are needed to ensure patients stay on the path to recovery.

Becky Buhner, deputy director of addiction and forensic treatment for the DMHA, said the data will help policymakers craft targeted responses to addiction-recovery needs.

"We can then look at a ZIP code to determine if there is an area of high need within that ZIP code," Buhner explained. "That's going to allow us to make funding decision in the future as to how we can better allocate our resources to meet the needs of that area."

People can complete the survey online or by texting "RECOVERY" to 833-638-3784. Buhner said the state wants to hear from a wide variety of people, including those currently using drugs, those in recovery, and their family and friends.

The state said it has allocated more than $45 million in grant funding over the past four years to combat the opioid epidemic. Buhner pointed out Indiana has spent years expanding its addiction-recovery infrastructure. But she noted there are people who need help who are not connected to the recovery system, and the survey will help state health officials learn about those needs.

"We released it on Friday, and as of Saturday morning, we had 234 people that signed up for the text-message series," reported. "We had 99 individuals that actually completed the Recovery Capital Index, which is a 43% response rate."

She added the data compiled from the survey will be made public after six months. According to provisional data from the Indiana Department of Health, the state saw more than 2,500 drug overdose deaths last year, a five-year high. About 80% of those deaths were due to opioids.

Ohio's overdose crisis has been heavily linked to the use of prescription painkillers or heroin, but it is not the case anymore. Health officials now warn historic levels of overdose deaths are being exacerbated by the availability of counterfeit pills laced with fentanyl, a potent and deadly synthetic drug.

Shabbir Imber Safdar, executive director of the Partnership for Safe Medicines, said fake pills are being sold as prescription painkillers such as OxyContin, the anxiety drug Xanax, and stimulant medications.

"There's a lot of young people who take Adderall, and they're not particularly careful about where they get their pills," Safdar pointed out. "I think we're going to see a rise in deaths in the 16-24 age range from fake Adderall made with fentanyl."

In May, two Ohio State University students died from suspected use of fake Adderall pills laced with fentanyl. Ohio is expected to report more than 5,200 overdose deaths for 2021, compared with just 327 in 1999.

Counterfeit medications are commonly sold through social media, on hidden sites on the "dark web" or in person by someone claiming they are real. Safdar noted an estimated four in 10 pills with fentanyl contains a potentially deadly dose.

"Even the first fake pill you ever take might kill you because if it has too much fentanyl, there's no time to get addicted, that first pill will kill you," Safdar stressed. "So it's really a game of Russian roulette when you take one of these pills that did not come from a pharmacy, which is the only safe source."

The Drug Enforcement Administration recently issued a Public Safety Alert about the rise in the lethality and availability of fake prescription pills containing fentanyl, and is encouraging people to only use prescription medications as directed by a medical professional and dispensed by a licensed pharmacist.

Online sales of counterfeit prescription pills containing fentanyl are on the rise, and experts say social media apps like Snapchat and TikTok are driving the surge, including in Tennessee.

Shabbir Safdar, executive director of the Partnership for Safe Medicines, said an alarming number of counterfeit prescription drug pills containing fentanyl are being bought online by teens and young adults.

"And in fact, just in the last four years, we've tracked fatalities in 19 different states from people who've met a drug trafficker on Snapchat and then bought a fake pill," Safdar reported.

According to the Tennessee Department of Mental Health and Substance Abuse Services, more than 2,000 Tennesseans died of fentanyl-related drug overdoses in 2020, more than double the number in 2019.

Tennessee is one of many states recently passing laws decriminalizing fentanyl test strips in an effort to reduce deaths. The tests work by dipping the strip in water containing dissolved drugs.

Safdar noted he believes strips should be legal, but pointed out they do not always detect fentanyl in large batches.

"In fact, there's a young man in Tennessee that we profiled in the last couple of years, who he and his friends all order Xanax off the dark Web, and they each took a pill," Safdar recounted. "It was only this young man's that had the fatal amount of fentanyl in it."

Safdar pointed out more Americans are turning to online pharmacies for acetaminophen, aspirin, blood thinners and other routine medications, but said there's risk in buying products from any source other than a licensed pharmacy.

"During the pandemic, as many as one in seven Americans went online to purchase medication, and many of them went to these fake Canadian pharmacy websites," Safdar emphasized.

According to a study in the Journal of the American Pharmacies Association, there are more than 11,000 websites based in the U.S. and Canada calling themselves "pharmacies" and selling drugs online.